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Updated: Jun 6, 2025

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss

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Spatially Localized Visual Perception Estimation by Means of Prosthetic Vision Simulation.

Diego Luján Villarreal¹, Wolfgang Krautschneider²

¹Departamento de Mecatrónica y Biomédica, Escuela de Ingeniería y Ciencias, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey 64700, Mexico.

Journal of Imaging

|November 26, 2024

Summary

This study compares 2D and 3D retinal electrode arrays for vision prosthetics. The 3D array shows potential for more selective stimulation of individual retinal cells, improving visual perception.

Keywords:

pixelized visual perception prosthetic vision retina implant single-cell selectivity visual phosphenes

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Published on: October 27, 2016

Area of Science:

Biomedical Engineering
Neuroscience
Ophthalmology

Background:

Retinal prosthetics aim to restore vision via electrical stimulation.
Understanding phosphene properties is crucial for device improvement.
Current 2D arrays offer limited, dot-like visual perceptions.

Purpose of the Study:

To analyze the impact of 2D and 3D electrode array designs on retinal stimulation.
To compare the cell selectivity and stimulation characteristics of different array topologies.
To establish a method for evaluating 3D electrode arrays for high-density, selective retinal cell activation.

Main Methods:

Developed a 3D computational model in COMSOL Multiphysics simulating retinal electrical stimulation.
Included retinal interface elements and voltage-gated ionic channel dynamics.
Verified cell stimulation and compared simulation findings with clinical data from 2D arrays.

Main Results:

Simulation results align with clinical observations for 2D arrays, enabling analytical models.
Identified distinct visual sensations evoked by 2D and 3D arrays.
The 3D array demonstrated potential for lower-threshold activation and improved cell selectivity compared to the 2D array.

Conclusions:

The 3D linear electrode array design shows promise for enhancing cell selectivity in retinal prostheses.
This design may allow for the activation of individual retinal ganglion cells (RGCs) at higher densities.
The study provides a proof-of-concept for utilizing 3D arrays for safe and selective RGC activation.