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Targeting Disulfidptosis with Potentially Bioactive Natural Products in Metabolic Cancer Therapy
Xinyan Li1,2, Jiayi Xu2, Liangwen Yan2
1Department of General Surgery, National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Background:
Metabolic cancers are defined by metabolic reprogramming. Although this reprograming drives rapid tumour growth and invasion, it also reveals specific metabolic vulnerabilities that can be therapeutically exploited in cancer therapy. A novel form of programmed cell death, known as disulfidptosis, was identified last year; tumour cells with high SLC7A11 expression undergo disulfidptosis when deprived of glucose. Natural products have attracted increasing attention and have shown potential to treat metabolic cancers through diverse mechanisms.
Methods:
We systematically searched electronic databases involving PubMed, Web of Science, Gooale Scholar. To ensue comprehensive exploration, keywords including metabolic reprogramming, metabolic cancer, disulfidptosis, natural products and some other words were employed.
Results:
In this review, we focus on the shared characteristics and metabolic vulnerabilities of metabolic cancers. Additionally, we discuss the molecular mechanisms underlying disulfidptosis and highlight key regulatory genes. Furthermore, we predict bioactive natural products that target disulfidptosis-related genes, offering new perspectives for anticancer strategies through the modulation of disulfidptosis.
Conclusions:
By summarizing current research progress, this review mainly analyzed the potential mechanisms of natural products in the treatment of metabolic cancer.
Insights
Metabolic cancers exploit reprogramming but have vulnerabilities. Natural products targeting disulfidptosis, a novel cell death pathway, offer new therapeutic strategies for metabolic cancers.
Area of Science:
- Oncology
- Metabolic pathways
- Cell death mechanisms
Background:
- Metabolic cancers exhibit reprogramming driving growth and invasion.
- This reprogramming creates unique metabolic vulnerabilities exploitable for therapy.
- Disulfidptosis, a novel cell death form, occurs in high SLC7A11 tumors lacking glucose.
Purpose of the Study:
- To review metabolic vulnerabilities in metabolic cancers.
- To discuss disulfidptosis mechanisms and regulatory genes.
- To identify natural products targeting disulfidptosis for cancer therapy.
Main Methods:
- Systematic literature search of PubMed, Web of Science, and Google Scholar.
- Keywords included metabolic reprogramming, metabolic cancer, disulfidptosis, and natural products.
- Analysis focused on shared characteristics, vulnerabilities, and therapeutic potential.
Main Results:
- Metabolic cancers share specific vulnerabilities.
- Disulfidptosis is a key pathway regulated by specific genes.
- Bioactive natural products targeting disulfidptosis-related genes were predicted.
Conclusions:
- Natural products show potential for treating metabolic cancers.
- Modulating disulfidptosis presents a novel anticancer strategy.
- Further research into natural products for metabolic cancer is warranted.
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