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Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and
Josie Dunn1, Fabrizio Schifano2, Ed Dudley1
1Medical School, The Grove, Swansea University, Singleton Campus, Wales SA2 8PP, UK.
Introduction:
Evidence suggests an increasing misuse of veterinary medicines by humans. This study aims to analyse Adverse Events (AEs) associated with selected veterinary products using the Food and Drug Administration Adverse Events Reporting System (FAERS).
Methods:
A descriptive pharmacovigilance analysis was conducted on AEs related to 21 drugs approved for human and/or animal use.
Results:
A total of 38,756 AEs, including 9566 fatalities, were identified. The United States reported the highest number of cases (13,532), followed by Canada (2869) and the United Kingdom (1400). Among the eight drugs licenced exclusively for animals, levamisole, pentobarbital, and xylazine were most frequently reported. Reports predominantly involved males (57%) from the 18-64 age group, with incidents related mainly to overdose, dependence, and multi-agent toxicities. Unmasking techniques revealed 'intentional overdose' as the primary reaction. Polysubstance use was evident in 90% of the drugs, with benzodiazepines/Z-drugs and opioids as common co-used classes.
Conclusions:
Veterinary medications are increasingly infiltrating the illicit drug market due to their pharmacological properties. This trend highlights the need for heightened vigilance and awareness to prevent further public health risks associated with the adulteration of illicit substances with veterinary products like xylazine and pentobarbital.
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