Dietary Mycotoxins: An Overview on Toxicokinetics, Toxicodynamics, Toxicity, Epidemiology, Detection, and Their Mitigation with Special Emphasis on Aflatoxicosis in Humans and Animals
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Aflatoxin B1 (AFB1) is a toxic fungal contaminant in food. More research is needed on AFB1 poisoning, its risks, and effective mitigation strategies for human and animal health.
Area Of Science
- Food science
- Toxicology
- Public health
Background
- Mycotoxins, produced by fungi, are common food contaminants.
- Aflatoxins, especially aflatoxin B1 (AFB1), pose significant public health risks due to their toxicity.
- Understanding AFB1 poisoning is crucial for developing effective control measures.
Purpose Of The Study
- To review current knowledge on mycotoxin poisoning, focusing on aflatoxicosis in humans and animals.
- To identify knowledge gaps in AFB1 toxicology, epidemiology, and mitigation.
- To discuss challenges and propose future research directions.
Main Methods
- Literature review of mycotoxin poisoning, particularly aflatoxicosis.
- Analysis of existing data on AFB1 prevalence, toxicology, and impact.
- Discussion of hypotheses on mycotoxin functions in fungi and epidemiological data.
Main Results
- Significant knowledge gaps exist regarding AFB1 poisoning mechanisms and effects.
- Reliable sampling methods for AFB1 in animal feed are lacking.
- The risk of cancer from dietary AFB1 requires further quantification.
Conclusions
- Prioritizing identification of high-risk foods and quantifying cancer risks from AFB1 is essential.
- Further research on AFB1 in animal feed, its impact on animal production, and risk factors is needed.
- Predictive surveillance and biocontrol strategies show promise for reducing aflatoxin burden.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...