Pan-cancer analysis identifies the oncogenic role of CCNE1 in human cancers
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Updated: Jun 6, 2025

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
Yujie Ouyang1, Ziyi Wu2, Dilihumaer Aili3
1Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Objective:
To investigate expression, prognosis, immune cell infiltration of Cyclin E1 (CCNE1) in cancer.
Methods:
We used TIMER and GEPIA datasets to analyze the differential expression of CCNE1 in multiple tumors. GEPIA and Kaplan-Meier plotter databases were utilized to observe the prognostic significance of CCNE1 in cancer. TIMER and cBioPortal databases were adopted for the analysis regarding immune infiltration and mutation respectively.
Results:
The results showed that CCNE1 was highly expressed in multiple cancers including BLCA, BRCA, CHOL, COAD, ESCA, HNSC, KICH, KIRC, KIRP, LIHC, LUAD, LUSC, READ, STAD, THCA, UCEC (P < 0.001) and CESC (P < 0.01). High CCNE1 expression was associated with a poor overall survival prognosis in several cancers, including ACC, BRCA, KIRC, KIRP, LGG, LIHC, LUAD and MESO. Additionally, CCNE1 expression was correlated with the cancer-associated immune infiltration level in BRCA, COAD, LUSC, STAD and THYM.
Conclusions:
CCNE1 is expected to be a potential biomarker for tumor prognosis and immune infiltration in various cancers.
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