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Experimental and numerical study of solid needle insertions into human stomach tissue.

Sif Julie Friis1, Torben Stroem Hansen2, Camilla Olesen3

  • 1Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark; Alternative Delivery Technologies, Device & Delivery Solutions, Novo Nordisk A/S, Hilleroed, Denmark.

Journal of the Mechanical Behavior of Biomedical Materials
|November 26, 2024
PubMed
Summary

Needle insertion into the stomach wall was studied experimentally and numerically. Results show that needle shape and insertion speed significantly impact tissue mechanics, guiding oral device development.

Keywords:
Biomechanical propertiesComputational workExperimental workHuman stomach tissueNeedle insertionOral drug delivery devices

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Gastroenterology

Background:

  • Oral drug delivery is highly desirable but limited for macromolecular drugs due to poor bioavailability.
  • Oral devices offer a potential solution, yet understanding device-tissue interaction in the stomach is crucial.
  • Knowledge gaps exist regarding the mechanical interactions during needle insertion into gastric tissue.

Purpose of the Study:

  • To investigate needle insertion mechanics into human gastric tissue.
  • To develop and validate a numerical model for simulating needle-tissue interactions.
  • To inform the early design stages of oral drug delivery devices.

Main Methods:

  • Experimental needle insertions into excised human gastric tissue using sharp and blunt needles at varying velocities.
  • Determination of constitutive model parameters through tensile visco-hyperelastic biomechanical testing.
  • Development of a computational model simulating needle indentations with varied shapes and velocities.

Main Results:

  • Peak insertion forces were significantly influenced by needle geometry (p < 0.05).
  • A validated numerical model (R² = 0.973) accurately predicted tissue response.
  • Both needle shape and insertion velocity affected stress, displacement, and energy absorption in the gastric tissue.

Conclusions:

  • This study enhances understanding of needle insertion into the stomach wall.
  • The validated numerical model serves as a valuable tool for early-stage oral device development.
  • Insertion velocity and needle geometry are critical factors influencing mechanical outcomes during gastric needle insertion.