Quercetin-based biomaterials for enhanced bone regeneration and tissue engineering

Quercetin, a natural flavonoid, has been extensively researched for its potential in promoting bone regeneration and tissue engineering. This review aimed to provide a comprehensive overview of the applications of quercetin-based biomaterials in bone regeneration and tissue engineering. The review discusses several studies that have integrated quercetin into biomaterials such as electrospun fibers, hydrogels, microspheres, and nanoparticles. These biomaterials are engineered to imitate the natural extracellular matrix of bone, creating an environment conducive to cell attachment, growth, and differentiation. The investigations presented emphasize the potential of quercetin-derived biomaterials in improving bone regeneration, decreasing oxidative stress and inflammation, and facilitating bone tissue restoration. These biomaterials have demonstrated the ability to facilitate cell encapsulation, maintain consistent quercetin release patterns, and have been applied in a range of uses such as bone grafts, implants, and tissue engineering scaffolds. Biomaterials derived from quercetin are utilized in the treatment of bone-related disorders, including osteoporosis and bone defects. These materials enhance bone regeneration by providing a scaffold for new bone growth, promoting the development of new bone tissue, and improving the mechanical properties of bone tissue.