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Updated: Jun 6, 2025

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Published on: March 13, 2014
Peripheral fatty acids and outcome of assisted reproduction
Valentina De Cosmi1, Sonia Cipriani2, Marie-Louise Syren3
1Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy; Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, Università degli Studi di Milano, Milan, Italy.
Objectives:
The present study investigated the relationship between fatty acid levels in whole blood in women undergoing in vitro fertilization and four successive assisted reproductive technology (ART) outcomes.
Methods:
A cross-sectional study was performed on data from a prospective cohort study conducted between 2014 and 2016.
Results:
Participants were 238 women undergoing in vitro fertilization and participating in a study on the role of lifestyle habits and diet in ART outcomes. Blood polyunsaturated fatty acids were measured by gas chromatography. Overall, higher blood levels of monounsaturated fatty acids and oleic acid and higher ω-6/ω-3 ratio and arachidonic/docosahexaenoic acid ratio were associated with more favorable ART outcomes. By contrast, higher concentrations of long chain polyunsaturated fatty acids tended to be negatively associated with the considered outcomes.
Conclusions:
Further prospective studies are needed to determine the ranges of fatty acid concentrations that are optimal for women with subfertility.
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