Flexible coatings based on hydrogel to enhance the biointerface of biomedical implants

The use of biomedical implants in surgical techniques promotes the restoration of lost tissue or organ physiological functions in the body. The interface between different materials determines their interactions and ultimately affects the physicochemical properties of biomedical implants. After implantation, the biointerface plays a crucial role in determining the biocompatibility and functionality of biomedical implants. Surface modification of biomaterials by developing novel biomaterials like various flexible coatings to meet the requirements of biointerfaces, such as mechanical performance, compatibility safety, and biological activities, can improve material-biological interactions by maintaining its original volumetric characteristics. Hydrogels possess excellent plasticity, biodegradability, biocompatibility, and extracellular-matrix-like properties, making them widely used in the biomedical field. Moreover, due to their unique three-dimensional crosslinked hydrophilic network, hydrogels can encapsulate a variety of materials, such as small molecules, polymers, and particle. In recent years, it has been proved that coating biomedical implant materials with flexible hydrogels can optimize the biointerface and holds vast potential for implant surface modification. In this review, we first discussed the potential requirements of the biointerface on the surface of implantable materials in both in vitro and in vivo biological microenvironments. Based on these comprehensive reviews, we also introduced the potential applications of hydrogels in both in vitro and in vivo settings. Finally, this review focused on the challenges faced by the biointerface of implantable materials constructed based on hydrogels and proposed future approaches to inspire researchers with new ideas.