Case Report of Asymptomatic Kikuchi-Fujimoto Disease

Kikuchi-Fujimoto Disease (KFD) is a rare condition, distinguished by its hallmark presentation of regional lymphadenopathy in young adult females. While initially observed to exclusively affect cervical lymph nodes in females under 40 years old, KFD is now known to impact individuals of any age or gender and manifest with adenopathy in various anatomical sites. Nonspecific imaging findings for KFD include enlarged lymph nodes, often exhibiting abnormal morphology.

In this study, we present the case of a 49 year old asymptomatic woman, in whom several enlarged left axillary lymph nodes were incidentally noted during routine mammography. The diagnosis of KFD was determined via ultrasound-guided core needle biopsy. Histological examination of the biopsied lymph node revealed necrotizing lymphadenitis, consistent with KFD.

The uncommon and broad presentation of KFD highlights the significance of acquiring tissue samples to distinguish this condition from resembling malignancies or autoimmune disorders.