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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Aortic valve sclerosis is not a benign finding but progressive disease associated with poor cardiovascular outcomes

Jeong Hun Seo1, Kwang Jin Chun1, Bong-Ki Lee1

  • 1Division of Cardiology, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Republic of Korea.

Journal of Cardiovascular Imaging
|November 27, 2024
PubMed

Insights

Aortic valve sclerosis progression significantly increases cardiovascular mortality risk. Monitoring patients with AVS progression is crucial for better cardiovascular outcomes.

Area of Science:

  • Cardiology
  • Echocardiography
  • Vascular Biology

Background:

  • Aortic valve sclerosis (AVS) shares atherosclerosis risk factors.
  • The link between AVS progression and cardiovascular (CV) risk is under-researched.

Purpose of the Study:

  • To investigate cardiovascular outcomes in patients based on AVS progression.
  • To identify predictors of AVS progression.

Main Methods:

  • Included 2,901 patients with AVS and serial echocardiograms (≥1 year apart).
  • Defined primary outcome as CV death, myocardial infarction, stroke, or revascularization.
  • Analyzed predictors of AVS progression using stepwise regression.

Main Results:

  • 15.1% of AVS patients progressed to aortic stenosis over a median of 3.9 years.
  • AVS progression was associated with older age, atrial fibrillation, peripheral artery disease, and increased left ventricular mass index.
  • Patients with AVS progression had significantly higher rates of adverse CV events (P < 0.0001).
  • AVS progression was an independent predictor of CV mortality (HR, 1.33; 95% CI, 1.10-1.61).

Conclusions:

  • AVS progression is an independent risk factor for cardiovascular mortality.
  • Patients with AVS progression may benefit from intensified cardiovascular risk management and monitoring.
Abstract

Keywords:
Aortic valve diseasesCardiovascular riskDisease progressionEchocardiography

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