Research progress on factors affecting the human milk metabolome

Area of Science:

• Nutritional Science
• Biochemistry
• Metabolomics

Background:

• Human milk is crucial for infant nutrition, containing diverse nutrients and bioactive compounds.
• Human milk composition is dynamic and complex, posing analytical challenges.
• Metabolomics offers a powerful approach to identify and analyze human milk metabolites.

Purpose of the Study:

• To systematically review the current state of human milk metabolomic research.
• To analyze factors influencing human milk metabolite profiles and their implications.
• To provide insights for advancing human milk metabolomics for infant health.

Main Methods:

• Systematic literature review of human milk metabolomic studies.
• Analysis of various metabolomic methodologies applied to human milk.
• In-depth examination of factors affecting human milk metabolite profiles.

Main Results:

• Identification of key metabolite classes in human milk using metabolomics.
• Understanding the dynamic nature of human milk metabolites and influencing factors.
• Highlighting the potential of metabolomics to link infant nutrition with health outcomes.

Conclusions:

• Human milk metabolomics is a rapidly advancing field with significant implications for infant nutrition.
• Further research is needed to fully elucidate the role of milk metabolites in infant development.
• This review provides a foundation for future advancements in human milk metabolomics.