Related Experiment Video
Updated: Jun 6, 2025

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
Synergy as the Failure of Distributivity
Ivan Sevostianov1, Ofer Feinerman1
1Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 7610001, Israel.
Abstract:
The concept of emergence, or synergy in its simplest form, is widely used but lacks a rigorous definition. Our work connects information and set theory to uncover the mathematical nature of synergy as the failure of distributivity. For the trivial case of discrete random variables, we explore whether and how it is possible to get more information out of lesser parts. The approach is inspired by the role of set theory as the fundamental description of part-whole relations. If taken unaltered, synergistic behavior is forbidden by the set-theoretic axioms. However, random variables are not a perfect analogy of sets: we formalize the distinction, highlighting a single broken axiom-union/intersection distributivity. Nevertheless, it remains possible to describe information using Venn-type diagrams. The proposed multivariate theory resolves the persistent self-contradiction of partial information decomposition and reinstates it as a primary route toward a rigorous definition of emergence. Our results suggest that non-distributive variants of set theory may be used to describe emergent physical systems.
Related Concept Videos
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Secondary Distribution
In residential areas, 120/240 V single-phase, three-wire service is commonly used for lighting, outlets, and large appliances. Urban areas with high-density loads...
Singularity Functions for Shear
Agonism and Antagonism: Quantification
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
Convolution Properties I
The commutative property reveals that the input and the impulse response of an LTI (Linear Time-Invariant) system can be interchanged without affecting the output:
Transformers in Distribution System
Distribution substation transformers come in various ratings and typically use mineral oil for insulation and cooling. To prevent moisture and air from entering the oil, some transformers use an inert gas like nitrogen to fill the...

