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Prediction Models for Elevated Cardiac Biomarkers from Previous Risk Factors and During the COVID-19 Pandemic in

Joao Caballero-Vidal1, Jorge Luis Díaz-Ortega1,2, Irma Luz Yupari-Azabache2

  • 1Escuela Profesional de Nutrición, Universidad César Vallejo, Trujillo 13001, Peru.

Diagnostics (Basel, Switzerland)
|November 27, 2024
PubMed

Insights

Repeated COVID-19 infections correlate with elevated cardiac troponin inhibitor (cTnI) levels. Cardiovascular risk factors, like comorbidities and LDL, are linked to NT-proBNP, indicating potential cardiac damage prevention strategies.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Cardiac troponin (cTnI) indicates myocardial injury, while NT-proBNP signifies myocardial insufficiency.
  • Understanding associations between cardiovascular risk factors, SARS-CoV-2 infection history, and these biomarkers is crucial for cardiac health.
  • High prevalence of cardiovascular risk factors was noted in the study population.

Purpose of the Study:

  • To develop binary logistic regression models to assess the association of cardiovascular risk indicators, pre-pandemic history, SARS-CoV-2 infection frequency, and vaccination status with cTnI and NT-proBNP levels.
  • To identify predictors of elevated cardiac biomarkers in a Peruvian urban population.

Main Methods:

  • A cross-sectional study involving 281 residents of Trujillo, Peru, from September to December 2023.
  • Data collection included cardiovascular risk factors (obesity, glycemia, lipid profile), SARS-CoV-2 infection history, vaccination status, and serum concentrations of cTnI and NT-proBNP.
  • Binary logistic regression analysis was employed to determine associations.

Main Results:

  • High prevalence of abdominal obesity (55.2%), elevated glycemia (53%), hypercholesterolemia (49.8%), low HDL (71.9%), and high LDL (78.6%) were observed.
  • A significant association was found between the number of SARS-CoV-2 infections and elevated cTnI levels (OR = 3.513, p = 0.003).
  • The number of comorbidities (OR = 2.185, p = 0.025) and LDL levels (OR = 0.209, p = 0.025) were associated with NT-proBNP levels.

Conclusions:

  • Increased SARS-CoV-2 infection frequency is linked to higher cTnI levels, suggesting a potential for myocardial injury.
  • Comorbidities and LDL cholesterol levels are associated with NT-proBNP, highlighting their role in myocardial insufficiency.
  • These findings contribute to understanding and preventing cardiac damage in the context of cardiovascular risk and viral infections.

Keywords:
cardiac troponin Icholesterolcomorbiditydyslipidemiametabolic syndromenatriuretic peptide

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