Elevated Calprotectin Levels Reveal Loss of Vascular Pattern and Atrophy of Villi in Ileum by Digital Chromoendoscopy and Magnification Colonoscopy in Patients with Spondyloarthritis Without Having Inflammatory Bowel Disease
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Fecal calprotectin (FC) levels are elevated in spondyloarthritis (SpA) patients, correlating with intestinal inflammation and ileal damage. High FC indicates potential gut involvement, suggesting FC as a biomarker for SpA management.
Area Of Science
- Gastroenterology
- Rheumatology
- Immunology
Background
- Spondyloarthritis (SpA) is a group of inflammatory diseases affecting the spine and joints.
- Intestinal inflammation is common in SpA, but its detection can be challenging.
- Fecal calprotectin (FC) is a marker of intestinal inflammation.
Purpose Of The Study
- To investigate the correlation between fecal calprotectin (FC) levels and intestinal inflammation in SpA patients without inflammatory bowel disease.
- To assess the utility of FC as a biomarker for gut involvement in SpA.
Main Methods
- 180 SpA patients were included in the study.
- Fecal calprotectin (FC), C-reactive protein (CRP), HLA-B*27, and clinical indices were assessed.
- Digital chromoendoscopy (DCE) was performed in a subset of patients.
Main Results
- Elevated FC levels (positive FC: 27.0%, high FC: 16.0%) were observed in SpA patients.
- High FC correlated with higher functional (BASFI) and disease activity (BASDAI) scores.
- Loss of vascular pattern in the ileum (LVPI), indicative of inflammation, was associated with positive FC and symptoms like abdominal bloating and pain.
- Chronic ileal inflammation correlated significantly with high FC, LVPI, and villous atrophy.
Conclusions
- FC levels are significantly elevated in SpA patients, particularly those with ileal inflammation (LVPI).
- FC shows potential as a valuable biomarker for managing SpA, especially when joint manifestations coincide with ileal villous atrophy.
- The findings suggest a shared immune pathway contributing to chronic gut damage in SpA.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Strictureplasty
Proctocolectomy or total colectomy with ileostomy
Restorative proctocolectomy with Ileal pouch-anal anastomosis
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...