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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma

José Daniel Escobar Moreno1, José Luis Fajardo Castiblanco1, Laura Camila Riaño Rodriguez1

  • 1Semillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, Colombia.

Antioxidants (Basel, Switzerland)
|November 27, 2024
PubMed

Insights

Reactive oxygen species (ROS) cause oxidative stress, impacting melanoma. MicroRNAs (miRNAs) are linked to this stress and epigenetic changes in melanoma, suggesting a potential therapeutic target.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Reactive oxygen species (ROS) are key intermediates in redox reactions, influencing cell behavior via signaling pathways.
  • Oxidative stress, an imbalance between ROS and antioxidant defenses, is implicated in various pathophysiological conditions.
  • Melanoma pathogenesis and progression are associated with differential modulation of ROS-mediated oxidative stress and altered redox homeostasis.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in modulating signaling pathways related to ROS-mediated oxidative stress in melanoma.
  • To explore the functional link between redox homeostasis imbalance, the tumor microenvironment, and miRNA expression in melanoma.
  • To elucidate potential epigenetic network regulation mechanisms where oxidative stress modulation is a common factor in melanoma.

Main Methods:

  • Literature review focusing on the interplay between ROS, oxidative stress, miRNAs, and melanoma.
  • Analysis of existing evidence on miRNA-mediated epigenetic reprogramming in melanoma.
  • Synthesis of findings regarding signaling pathways modulated by miRNAs in the context of oxidative stress in melanoma.

Main Results:

  • Evidence suggests a functional link between altered redox homeostasis and miRNA-mediated epigenetic reprogramming in melanoma.
  • miRNAs play a role in modulating signaling pathways involved in ROS-mediated oxidative stress within the melanoma context.
  • The complex relationship between ROS control, the tumor microenvironment, and miRNA expression in melanoma requires further investigation.

Conclusions:

  • miRNAs are involved in regulating ROS-mediated oxidative stress signaling in melanoma.
  • Understanding the miRNA-epigenetic-oxidative stress axis in melanoma may reveal novel therapeutic strategies.
  • Oxidative stress modulation is a significant, yet underexplored, factor in melanoma's epigenetic landscape.
Keywords:
ROSmelanomamiRNAsoxidative stressredox homeostasis

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