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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: May 10, 2026

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

Editorial for Special Issue "Brain Tumor Microenvironment".

Gianluca Trevisi^1,2, Annunziato Mangiola¹

¹Department of Neurosciences, Imaging and Clinical Sciences, G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.

|November 27, 2024

Summary

This summary is machine-generated.

The tumor microenvironment (TME) impacts cancer progression and treatment outcomes. Understanding the TME is crucial for developing effective cancer therapies.

Area of Science:

Oncology
Cancer Biology
Immunology

Background:

The tumor microenvironment (TME) comprises cellular and non-cellular components that regulate tumor progression.

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Last Updated: May 10, 2026

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The TME critically influences tumor growth, metastasis, and therapeutic responses.

Key TME components include cancer cells, immune cells, fibroblasts, and the extracellular matrix.