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The Role of Early Child Nutrition in Pulmonary Hypertension-A Narrative Review

Alina-Costina Luca1, Cristina Stoica2, Cosmin Diaconescu1

  • 1Department of Pediatrics, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, RO-700115 Iasi, Romania.

Children (Basel, Switzerland)
|November 27, 2024
PubMed

Insights

Pediatric pulmonary hypertension is influenced by nutrition. Deficiencies in vitamins C, D, and iron worsen outcomes, while nutrients like resveratrol and microbiome modulation show promise for management.

Area of Science:

  • Pediatric Pulmonology
  • Nutritional Science
  • Clinical Research

Background:

  • Pulmonary hypertension (PH) presents unique challenges in children.
  • Early childhood nutrition significantly impacts pediatric PH growth, progression, and management.
  • Nutritional deficiencies are linked to poorer outcomes in pediatric PH.

Purpose of the Study:

  • To review the role of early childhood nutrition in pediatric pulmonary hypertension.
  • To identify key nutrients and interventions for managing pediatric PH.
  • To highlight research gaps in pediatric-specific nutritional studies.

Main Methods:

  • Literature review focusing on pediatric pulmonary hypertension and nutrition.
  • Analysis of studies on nutritional deficiencies (vitamins C, D, iron).
  • Exploration of emerging therapeutic nutrients (resveratrol) and microbiome modulation.

Main Results:

  • Nutritional deficiencies (vitamins C, D, iron) correlate with worse pediatric PH outcomes.
  • Early nutritional intervention is crucial for preventing malnutrition and promoting growth.
  • Resveratrol and microbiome modulation are potential therapeutic avenues.

Conclusions:

  • Targeted nutritional interventions are needed to improve pediatric PH outcomes.
  • More pediatric-specific research is essential, as current data is often extrapolated from adults and animal models.
  • Addressing nutritional status is vital for comprehensive pediatric PH management.

Keywords:
malnutritionmicrobiomenutritionpulmonary hypertensionresveratrolvitamin

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