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The Impact of Inflammatory Markers and Obesity in Chronic Venous Disease

Flavia-Medana Petrascu1,2, Sergiu-Ciprian Matei3,4, Mădălin-Marius Margan5,6

  • 1Department of Doctoral Studies, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timișoara, Romania.

Biomedicines
|November 27, 2024
PubMed

Insights

Inflammation markers like C-reactive protein (CRP) and fibrinogen, along with age and absolute neutrophil count (ANC), predict chronic venous disease (CVD) severity, especially in obese patients. Obesity indirectly impacts CVD via these inflammatory markers.

Area of Science:

  • Vascular Medicine
  • Inflammology
  • Obesity Research

Background:

  • Chronic venous disease (CVD) poses a significant health burden, with obesity exacerbating its impact.
  • Understanding the role of inflammation in CVD progression is crucial for effective management.

Purpose of the Study:

  • To investigate the relationship between inflammatory markers, obesity, and the progression of chronic venous disease.
  • To identify key predictors of CVD severity in a patient cohort.

Main Methods:

  • Analysis of clinical and paraclinical data from 619 patients treated for CVD between 2018 and 2024.
  • Statistical analysis including logistic regression to identify predictors of CVD progression.
  • Evaluation of inflammatory markers such as C-reactive protein (CRP) and fibrinogen, alongside body-mass index (BMI) and absolute neutrophil count (ANC).

Main Results:

  • Age, CRP, fibrinogen, and ANC were identified as significant predictors of CVD progression.
  • Elevated CRP and fibrinogen levels strongly correlated with increased CVD severity, particularly in obese individuals (higher BMI).
  • A predictive model incorporating age, BMI, CRP, fibrinogen, and ANC achieved high accuracy (AUC = 0.902) for risk stratification.

Conclusions:

  • A validated predictive model can effectively stratify patients at risk for severe CVD.
  • Inflammation emerges as a critical therapeutic target for managing chronic venous disease, especially in the context of obesity.

Keywords:
chronic venous diseaseendothelial dysfunctioninflammationmicrocirculatory damageobesity

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