Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

O2 transport in cerebral microregions (mathematical simulation).

Kislyakov YuYa, K P Ivanov

    Journal of Biomechanical Engineering
    |February 1, 1986
    PubMed
    Summary

    Mathematical modeling reveals that capillary circulation and nerve cell oxygen consumption significantly impact oxygen tension in the brain. Regulatory adjustments in capillary flow can maintain consistent oxygen supply across cerebral microregions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [A balance between surgical management and therapy in a patient with severe sternomediastinitis complicated by heart failure and refractory septic shock].

    Khirurgiia·2024
    Same author

    [The use of autologous platelet-rich plasma in the treatment of chronic pharyngitis].

    Vestnik otorinolaringologii·2024
    Same author

    [A new paradigm for the treatment of sternomediastinitis].

    Khirurgiia·2023
    Same author

    Maintenance of the Cardiovascular Function in a Deeply Cooled Homeothermic Organism by Physiological Methods without External Rewarming.

    Bulletin of experimental biology and medicine·2016
    Same author

    [Physiological problems of alveolar circulation in the lungs].

    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·2015
    Same author

    [Diagnostic capabilities of single-photon emission computed tomography/computed tomography in the evaluation of perfusion disorders in pulmonary hypertension].

    Vestnik rentgenologii i radiologii·2015

    Area of Science:

    • Neuroscience
    • Physiology
    • Mathematical Biology

    Background:

    • Oxygen tension distribution in the cerebral cortex is critical for neuronal function.
    • Understanding the interplay between cerebral microcirculation, oxygen consumption, and tissue oxygen levels is essential.

    Purpose of the Study:

    • To investigate the effects of capillary circulation rate, nerve cell oxygen consumption, and capillary network density on oxygen tension distribution in the cerebral cortex.
    • To quantify the contributions of these factors to changes in local oxygen supply.

    Main Methods:

    • Development of a mathematical model simulating neuron-capillary relationships in the cerebral cortex.
    • The model was formulated as a system of partial differential equations.
    • Numerical solution using the net-point method.

    Main Results:

    • Regulatory variations in capillary circulation rate can ensure uniform oxygen supply changes within cerebral microregions.
    • Increased nerve cell oxygen consumption primarily lowers tissue pO2 (75% due to consumption, 25% due to reduced capillary pO2).
    • Decreased nerve cell oxygen consumption primarily increases tissue pO2 (75% due to capillary pO2 rise, 25% due to reduced consumption).
    • Capillary network density variations influence oxygen supply, with 1/3 attributed to capillary pO2 changes and 2/3 to diffusion distance alterations.

    Conclusions:

    • Capillary circulation rate is a key regulator of oxygen supply in the brain.
    • Both oxygen consumption by neurons and capillary oxygen levels significantly modulate tissue oxygen tension.
    • Capillary network density plays a substantial role in determining oxygen diffusion efficiency.

    Related Experiment Videos