Neuroradiological Findings in Cerebral Amyloid Angiopathy with a Particular Consideration of the Boston Criteria 2.0:...

Area of Science:

• Neurology
• Neuroradiology
• Pathology

Background:

• Cerebral amyloid angiopathy (CAA) is the primary cause of lobar intracranial hemorrhages in the elderly.
• CAA results from amyloid-beta fibril deposition in cerebral and leptomeningeal vessels.
• Accurate diagnosis is critical to prevent misdiagnosis.

Purpose of the Study:

• To review the diagnostic criteria for CAA, focusing on the Boston Criteria 2.0.
• To emphasize typical and suggestive neuroradiological imaging findings for CAA diagnosis.

Main Methods:

• Review of diagnostic criteria for CAA, including the Boston Criteria 2.0.
• Emphasis on neuroradiological imaging findings.
• Discussion of clinical and histopathological findings.

Main Results:

• The Boston Criteria 2.0, updated in 2022, is the current diagnostic standard for CAA.
• Neuroradiological imaging plays an expanded role in the Boston Criteria 2.0.
• Typical and other suggestive imaging findings are crucial for diagnosis.

Conclusions:

• The Boston Criteria 2.0 provides a comprehensive framework for CAA diagnosis.
• Understanding imaging findings is essential for correct application of the criteria.
• Accurate diagnosis of CAA is vital for appropriate patient management.