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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

448
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Related Experiment Video

Updated: Jun 6, 2025

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Alzheimer's Disease: Understanding Motor Impairments.

Jesús Andrade-Guerrero1,2, Humberto Martínez-Orozco2, Marcos M Villegas-Rojas1,3

  • 1Laboratorio de Patogénesis Molecular, Laboratorio 4, Edificio A4, Carrera Médico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla 54090, Mexico.

Brain Sciences
|November 27, 2024
PubMed
Summary

Motor symptoms like gait issues and muscle weakness are common in Alzheimer's disease (AD). Early detection of these motor deficits may predict AD onset and improve patient care.

Keywords:
Alzheimer’s diseasebalancecardiorespiratory fitnesscoordinationgaitmotor impairmentsmuscle atrophyneuromuscularposturestrength loss

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Area of Science:

  • Neurodegenerative Disorders
  • Geriatric Medicine
  • Neurology

Background:

  • Alzheimer's disease (AD) is the primary cause of dementia globally, significantly affecting patient health and quality of life.
  • While cognitive decline is characteristic, motor symptoms in AD are prevalent yet underexplored, often linked to advanced stages and increased mortality.

Purpose of the Study:

  • To conduct an in-depth review of motor symptoms in Alzheimer's disease.
  • To analyze the progression, underlying mechanisms, and potential therapeutic strategies for motor deficits in AD.
  • To highlight the potential of motor symptoms as early predictive markers for AD in older adults.

Main Methods:

  • Comprehensive literature review of existing research on motor symptoms in Alzheimer's disease.
  • Analysis of identified pathways implicated in the development of motor deficits.
  • Discussion of current and potential therapeutic interventions targeting motor dysfunction.

Main Results:

  • Motor symptoms in AD encompass gait disturbances, reduced cardiorespiratory fitness, muscle weakness, sarcopenia, and impaired balance.
  • Emerging evidence suggests motor symptoms may appear in early AD stages and can serve as predictive markers.
  • Key biological pathways contributing to motor symptoms in AD have been identified, warranting further investigation.

Conclusions:

  • Motor symptoms are a significant, often overlooked, aspect of Alzheimer's disease progression.
  • Early identification and management of motor symptoms alongside cognitive decline can improve patient functionality and quality of life.
  • Further research into the mechanisms and treatments for motor symptoms is crucial for comprehensive AD management.