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Delayed Recovery After Exercise-Induced Pain in People with Chronic Widespread Muscle Pain Related to Cortical
Mark D Bishop1,2, Meryl J Alappattu1,2, Priyanka Rana3
1Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA.
Brain Sciences
|November 27, 2024
Summary
People with chronic widespread muscle pain experience heightened pain and slower recovery after exercise-induced muscle soreness compared to healthy individuals. Brain connectivity differences may explain these responses to muscle microtrauma.
Area of Science:
- Neuroscience
- Pain Research
- Exercise Physiology
Background:
- A subset of patients with chronic pain report worsening symptoms after exercise.
- Delayed onset muscle soreness (DOMS) is a common outcome of high-intensity exercise.
Purpose of the Study:
- To investigate the exercise response in individuals with chronic widespread muscle pain (CWMP).
- To compare pain perception and recovery following a standardized exercise protocol between individuals with CWMP and pain-free controls.
- To explore the association between brain functional connectivity and pain responses.
Main Methods:
- Ten participants with CWMP and ten pain-free (NP) controls underwent a standardized DOMS protocol.
- Pain intensity at rest and during movement was tracked daily via electronic diaries.
- Functional connectivity of sensorimotor (SMN), cerebellum, frontoparietal control (FPN), and default mode networks (DMN) was assessed and correlated with pain variables.
Main Results:
- Participants with CWMP reported significantly higher peak pain, delayed peak pain onset, and prolonged recovery time for both resting and movement pain compared to NP controls.
- Pain catastrophizing and resilience were controlled for in the analysis.
- Functional connectivity within the SMN, FPN, and DMN was significantly associated with pain-related variables, with notable group differences observed.
Conclusions:
- A standardized muscle microtrauma protocol induced a more severe and prolonged pain response in individuals with CWMP.
- Differences in brain network connectivity, particularly in sensorimotor integration and appraisal regions, are linked to altered responses to muscle trauma in CWMP.
- These findings suggest a potential dysregulation in the processing of muscle microtrauma in individuals with chronic pain conditions.
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