Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
Mitochondria01:37

Mitochondria

11.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
11.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyamine metabolism as a regulator of cellular and organismal aging.

Amino acids·2026
Same author

Caldomycin, a new guanidopolyamine produced by a novel agmatine homocoupling enzyme involved in homospermidine biosynthesis.

Scientific reports·2024
Same author

Inhibition of Polyamine Catabolism Reduces Cellular Senescence.

International journal of molecular sciences·2023
Same author

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Mediates Acrolein Cytotoxicity in Human Lung Cancer Cells.

International journal of molecular sciences·2023
Same author

Whole Blood Spermine/Spermidine Ratio as a New Indicator of Sarcopenia Status in Older Adults.

Biomedicines·2023
Same author

Putrescine Biosynthesis from Agmatine by Arginase (TtARG) in Thermus thermophilus.

Journal of biochemistry·2023

Related Experiment Video

Updated: Jun 6, 2025

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans
06:18

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

5.9K

Special Issue "Polyamines in Aging and Disease".

Takeshi Uemura1, Yusuke Terui2

  • 1Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado 350-0295, Japan.

International Journal of Molecular Sciences
|November 27, 2024
PubMed
Summary
This summary is machine-generated.

Polyamines are essential bioactive amines crucial for cellular functions. This study explores their vital roles in maintaining cellular health and organismal life.

More Related Videos

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

2.8K
Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
09:29

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

8.4K

Related Experiment Videos

Last Updated: Jun 6, 2025

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans
06:18

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

5.9K
Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

2.8K
Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
09:29

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

8.4K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Polyamines are ubiquitous polycationic molecules essential for cell growth, proliferation, and differentiation.
  • These compounds play critical roles in stabilizing nucleic acids and regulating gene expression.
  • Dysregulation of polyamine metabolism is linked to various diseases, including cancer and neurological disorders.

Discussion:

  • This research elucidates the fundamental mechanisms by which polyamines mediate essential cellular processes.
  • It highlights the intricate network of enzymes and transporters involved in polyamine homeostasis.
  • The findings underscore the importance of polyamines in maintaining genomic stability and cellular integrity.

Key Insights:

  • Polyamines are indispensable for DNA replication, transcription, and translation.
  • Cellular polyamine levels are tightly regulated to prevent toxicity and ensure proper function.
  • Specific polyamine derivatives show potential as therapeutic targets for diseases associated with metabolic imbalance.

Outlook:

  • Future research should focus on targeted modulation of polyamine pathways for therapeutic interventions.
  • Investigating the role of polyamines in aging and age-related diseases presents a promising avenue.
  • Developing novel diagnostic tools based on polyamine biomarkers could enhance early disease detection.