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Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
Published on: June 3, 2016
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Epigenetics in Heart Failure
Jamie Sin Ying Ho1, Eric Jou2,3, Pek-Lan Khong4,5
1Department of Cardiology, National University Heart Centre, Singapore 119228, Singapore.
International Journal of Molecular Sciences
|November 27, 2024
Summary
Epigenetic modifications like DNA methylation and histone changes play a key role in heart failure development. Research into epigenetic therapies offers potential for new heart failure treatments and biomarkers.
Area of Science:
- Cardiology
- Molecular Biology
- Genetics
Background:
- Heart failure is a growing global health concern with a poor prognosis.
- Epigenetic modifications are increasingly recognized as crucial drivers of pathological cardiac remodeling.
- Stress-activated signaling cascades and epigenetic signals regulate gene expression in heart failure.
Purpose of the Study:
- To review the current evidence on the role of epigenetic modifications in heart failure.
- To summarize the potential of epigenetic therapies for heart failure.
- To highlight the need for further research into epigenetics and heart failure therapeutics.
Main Methods:
- Review of existing scientific literature on epigenetics and heart failure.
- Analysis of DNA methylation and various histone modifications (acetylation, phosphorylation, ubiquitination, sumoylation).
- Summary of ongoing epigenetic therapy development and clinical trials.
Main Results:
- Epigenetic processes, including DNA methylation and histone modifications, are critical in translating environmental stress into genetic expression, leading to cardiac remodeling.
- Several epigenetic modifications are implicated in the pathophysiology of heart failure.
- Limited clinical trials of epigenetic therapies in heart failure are currently available.
Conclusions:
- Epigenetic modifications are integral to the development and progression of heart failure.
- Epigenetic therapies hold promise for novel treatments, biomarkers, and personalized medicine approaches for heart failure.
- Further elucidation of dynamic epigenome changes in heart failure is essential for therapeutic advancement.
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