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Updated: Jun 6, 2025

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
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Epigenetics in Heart Failure.

Jamie Sin Ying Ho1, Eric Jou2,3, Pek-Lan Khong4,5

  • 1Department of Cardiology, National University Heart Centre, Singapore 119228, Singapore.

International Journal of Molecular Sciences
|November 27, 2024
PubMed
Summary
This summary is machine-generated.

Epigenetic modifications like DNA methylation and histone changes play a key role in heart failure development. Research into epigenetic therapies offers potential for new heart failure treatments and biomarkers.

Keywords:
DNA methylationepigenetic modificationheart failurehistone modificationspersonalized medicine

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Area of Science:

  • Cardiology
  • Molecular Biology
  • Genetics

Background:

  • Heart failure is a growing global health concern with a poor prognosis.
  • Epigenetic modifications are increasingly recognized as crucial drivers of pathological cardiac remodeling.
  • Stress-activated signaling cascades and epigenetic signals regulate gene expression in heart failure.

Purpose of the Study:

  • To review the current evidence on the role of epigenetic modifications in heart failure.
  • To summarize the potential of epigenetic therapies for heart failure.
  • To highlight the need for further research into epigenetics and heart failure therapeutics.

Main Methods:

  • Review of existing scientific literature on epigenetics and heart failure.
  • Analysis of DNA methylation and various histone modifications (acetylation, phosphorylation, ubiquitination, sumoylation).
  • Summary of ongoing epigenetic therapy development and clinical trials.

Main Results:

  • Epigenetic processes, including DNA methylation and histone modifications, are critical in translating environmental stress into genetic expression, leading to cardiac remodeling.
  • Several epigenetic modifications are implicated in the pathophysiology of heart failure.
  • Limited clinical trials of epigenetic therapies in heart failure are currently available.

Conclusions:

  • Epigenetic modifications are integral to the development and progression of heart failure.
  • Epigenetic therapies hold promise for novel treatments, biomarkers, and personalized medicine approaches for heart failure.
  • Further elucidation of dynamic epigenome changes in heart failure is essential for therapeutic advancement.