Search

Search

Home
...
Research Domains Biomedical and Clinical Sciences Oncology and Carcinogenesis Predictive and prognostic markers
Research Domains
Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Predictive and prognostic markers
Oxidative Stress and Placental Pathogenesis: A Contemporary Overview of Potential Biomarkers and Emerging Therapeutics

Oxidative Stress and Placental Pathogenesis: A Contemporary Overview of Potential Biomarkers and Emerging Therapeutics

Ioana Vornic ^1,2, Victor Buciu ³, Cristian George Furau ², Pusa Nela Gaje ^4,5, Raluca Amalia Ceausu ^4,5, Cristina-Stefania Dumitru ^4,5, Alina Cristina Barb ^4,5, Dorin Novacescu ^4,5, Alin Adrian Cumpanas ⁶, Silviu Constantin Latcu ^3,6, Talida Georgiana Cut ^7,8, Flavia Zara ^4,5

Ioana Vornic ^1,2, Victor Buciu ³, Cristian George Furau ²

¹Doctoral School, Department Medicine, "Vasile Goldiș" Western University of Arad, Liviu Rebreanu Street, No. 86, 310414 Arad, Romania.
²Discipline of Gynecology, Department Medicine, Vasile Goldiş Western University, Liviu Rebreanu Boulevard, No. 86, 310414 Arad, Romania.
³Doctoral School, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
⁴Department II of Microscopic Morphology, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
⁵Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
⁶Department XV, Discipline of Urology, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
⁷Department XIII, Discipline of Infectious Diseases, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
⁸Center for Ethics in Human Genetic Identifications, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.

⁰Doctoral School, Department Medicine, "Vasile Goldiș" Western University of Arad, Liviu Rebreanu Street, No. 86, 310414 Arad, Romania.

International Journal of Molecular Sciences +

|

November 27, 2024

|

November 27, 2024

Related Experiment Videos

Contact us if these videos are not relevant.

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology <em>In Vivo</em>

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

See all related videos

View abstract on PubMed

Summary

This summary is machine-generated.

Oxidative stress impacts placental health, causing complications like preeclampsia. Early detection via biomarkers and targeted therapies show promise for at-risk pregnancies, though clinical use needs further research.

Area Of Science

Reproductive Biology
Pathophysiology
Biomarker Discovery

Background

Oxidative stress (OS) is integral to placental development and function.
Dysregulated OS contributes to pregnancy complications such as miscarriage, preeclampsia, and intrauterine growth restriction.

Purpose Of The Study

To review the role of OS in placental pathogenesis.
To identify novel biomarkers for early detection of pregnancy complications.
To explore emerging therapeutic strategies targeting placental OS.

Main Methods

Literature review of recent research on OS in placental pathophysiology.
Analysis of sources, mechanisms, and effects of OS.
Evaluation of diagnostic biomarkers and therapeutic interventions.

Main Results

Excessive OS, beyond physiological levels, leads to adverse pregnancy outcomes.
Malondialdehyde, 8-isoprostane, and sFlt-1/PlGF ratio are promising OS biomarkers.
Mitochondria-targeted antioxidants, Nrf2 activators, and gasotransmitter therapies show preclinical efficacy.

Conclusions

OS biomarkers offer potential for early detection of at-risk pregnancies.
Therapeutic strategies targeting OS require further clinical validation.
Future research should focus on large-scale biomarker studies and personalized therapies, including extracellular vesicles and nanomedicine.

Keywords:

DNA damage intrauterine fetal growth restriction maternal–placental–fetal interactions novel therapeutic approaches oxidative stress biomarkers placental molecular pathology pre-eclampsia pregnancy complications pregnancy loss/miscarriage trophoblast

Related Experiment Videos

Contact us if these videos are not relevant.

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology <em>In Vivo</em>

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

See all related videos

Related Concept Videos

Peroxisomes

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...

Share

X
Facebook
LinkedIn
YouTube

ABOUT JoVE

Overview
Leadership
Blog
JoVE Help Center

AUTHORS

Publishing Process
Editorial Board
Scope & Policies
Peer Review
FAQ
Submit

LIBRARIANS

Testimonials
Subscriptions
Access
Resources
Library Advisory Board
FAQ

RESEARCH

JoVE Journal
Methods Collections
JoVE Encyclopedia of Experiments
Archive

EDUCATION

JoVE Core
JoVE Business
JoVE Science Education
JoVE Lab Manual
Faculty Resource Center
Faculty Site

Terms & Conditions of Use
Privacy Policy
Policies