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Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

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Cannabidiol, a Strategy in Aging to Improve Redox State and Immunity in Male Rats.

Mónica De la Fuente^1,2, Noelia Joyera¹, Judith Félix^1,2

¹Department of Genetics, Physiology and Microbiology (Animal Physiology Unit), Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain.

International Journal of Molecular Sciences

|November 27, 2024

Summary

Cannabidiol (CBD) supplementation in aging rats improved antioxidant defenses and immune function. This suggests CBD may be a viable strategy for promoting healthier aging by combating oxidative stress and immunosenescence.

Keywords:

aging cannabidiol immunity oxidative stress rats spleen thymus whole blood cells

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Area of Science:

Gerontology
Immunology
Pharmacology

Background:

Aging is linked to increased oxidative stress and impaired immune function, contributing to higher morbidity.
Cannabidiol (CBD) possesses antioxidant properties, yet its specific effects on aging processes remain under-researched.

Purpose of the Study:

To investigate the impact of CBD on the redox state and immune system of aging rats.
To evaluate CBD's potential as an intervention for mitigating age-related decline.

Main Methods:

15-month-old male rats received daily CBD (10 mg/kg) in their diet for 10 weeks, compared to age-matched controls and young controls.
Analysis included spleen, thymus, and blood cell collection to assess redox parameters (glutathione, lipid peroxidation) and immune functions (chemotaxis, NK activity, lymphoproliferation).

Main Results:

Aging rats (15-month-old) exhibited elevated oxidative stress and immunosenescence compared to young controls.
CBD treatment in aged rats led to enhanced antioxidant defenses and reduced oxidative damage in spleen, thymus, and blood cells.
Immune functions in the spleen of CBD-treated rats were significantly improved compared to age-matched controls.

Conclusions:

CBD administration effectively counteracts oxidative stress and enhances immune responses in aging rats.
These findings suggest CBD as a potential therapeutic strategy for promoting healthy aging and combating age-related immune dysfunction.