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Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

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Published on: September 23, 2015

Tracing ALS Degeneration: Insights from Spinal Cord and Cortex Transcriptomes.

Nela Pragathi Sneha¹, S Akila Parvathy Dharshini¹, Y-H Taguchi²

¹Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, Tamilnadu, India.

|November 27, 2024

Summary

This summary is machine-generated.

Researchers identified shared molecular pathways in Amyotrophic Lateral Sclerosis (ALS) affecting the frontal cortex and spinal cord. Upregulated immune responses and downregulated metabolic processes are key in neurodegeneration, offering potential therapeutic targets.

Keywords:

ALS gene expression network neurodegenerative diseases transcriptome analysis

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Revealing Neural Circuit Topography in Multi-Color

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Published on: November 14, 2011

Area of Science:

Neuroscience
Genomics
Molecular Biology

Background:

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease causing motor neuron loss.
Neuronal death in ALS is linked to mitochondrial dysfunction, oxidative stress, and excitotoxicity.
The frontal cortex and spinal cord are critical for motor control and function.

Purpose of the Study:

To investigate transcriptome data from the frontal cortex and spinal cord in ALS.
To identify common pathological mechanisms and pathways in ALS.
To discover potential therapeutic targets for ALS.

Main Methods:

Gene and transcript expression patterns were quantified.
Computational tools were used to predict variants and assess functional effects.
Functional interaction networks and gene enrichment analyses were performed.

Main Results:

Novel genes involved in immune response upregulation were identified.
Metabolic-related and defective degradation processes were downregulated in both tissues.
Histone regulation and blood pressure-related genes were dysregulated in the frontal cortex.

Conclusions:

Distinct and shared molecular disruptions in ALS were highlighted.
Immune response and metabolic dysfunction play critical roles in neuronal degeneration.
Targeting identified pathways may offer new therapeutic strategies for ALS.