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Correction: Coulter et al. OrgTRx: A Platform Developed in Queensland for the Extraction and Visualisation of Antimicrobial Susceptibility Data for the Surveillance of Resistance in Microorganisms. <i>Antibiotics</i> 2026, <i>15</i>, 63.

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Antibiotic-Induced Immunosuppression-A Focus on Cellular Immunity.

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Antibiotics can harm cellular immunity by affecting mitochondrial function and impairing immune cell activities. Further research is needed to understand their clinical impact on patient immunity.

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Area of Science:

  • Immunology
  • Pharmacology
  • Microbiology

Background:

  • Antibiotics are crucial for treating bacterial infections but have known side effects.
  • Emerging evidence highlights the adverse effects of antibiotics on the immune system.
  • Direct impacts on cellular immunity are a key area of concern.

Purpose of the Study:

  • To review the direct effects of antibiotics on cellular immunity.
  • To explore the mechanisms by which antibiotics impair immune cell functions.
  • To synthesize findings from various in vivo and in vitro models.

Main Methods:

  • Literature review focusing on antibiotic effects on cellular immunity.
  • Analysis of studies examining antibiotic impact on mitochondrial function.
  • Compilation of data on immune cell functions like chemotaxis, phagocytosis, and proliferation.

Main Results:

  • Antibiotics directly affect cellular immunity through various mechanisms.
  • Impairment of mitochondrial function is a key pathway for antibiotic-induced immune dysfunction.
  • Specific immune cell functions including chemotaxis, phagocytosis, cytokine production, antigen presentation, and lymphocyte proliferation are negatively impacted.

Conclusions:

  • Antibiotics can directly impair cellular immunity, affecting multiple immune cell functions.
  • Further clinical research is necessary to elucidate the impact on patient immunity and outcomes.
  • Increased awareness and therapeutic drug monitoring may mitigate dose-dependent adverse effects.