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Tigecycline Containing Polymethylmethacrylate Cement Against MRSA, VRE, and ESBL-In Vitro Mechanical and
Michael Abramowicz1, Andrej Trampuz2, Klaus-Dieter Kühn3
1KABEG, LKH Villach, 9500 Villach, Austria.
Background:
The use of antibiotic-loaded bone cements (ALBCs) in arthroplasty has been well established for the prevention and treatment of infections. Tigecycline (Tig), a broad-spectrum antibiotic, has shown efficacy against various pathogens, including vancomycin-resistant strains.
Method:
ISO and DIN mechanical and microbiological inhibition zone tests were performed on PMMA cement with manually added Tigecycline.
Results:
Manually adding 0.5 and 1.0 g Tigecycline to PMMA always meets the mechanical requirements of ISO and DIN standards. Mixtures containing 0.5 g were microbiologically effective for up to 7 days and those containing 1.0 g were effective for 28-42 days.
Conclusion:
In revision surgery, manually adding Tigecycline in doses of 0.5-1 g to 40 g of PMMA is effective against MRSA, VRE, and ESBL without negatively affecting the cement's properties.
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