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Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
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  1. Home
  3. Research Domains
  5. Engineering
  7. Environmental Engineering
  9. Air Pollution Modelling And Control
  11. In-depth Analysis Of Olea Europaea L. Leaf Extract: Alleviating Pulmonary Histological Disturbances, Pro-inflammatory Responses, And Oxidative Stress From Isolated Or Combined Exposure To Inhaled Toluene And Noise In Rats

In-Depth Analysis of Olea europaea L. Leaf Extract: Alleviating Pulmonary Histological Disturbances, Pro-Inflammatory Responses, and Oxidative Stress from Isolated or Combined Exposure to Inhaled Toluene and Noise in Rats

Takoua Ben Attia1, Sana Bahri2,3,4, Sonia Ben Younes1,5

  • 1Laboratory of Research "LR 23/ES/10": Population Pathology, Environmental Aggressors, Alternative Therapy, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis 1068, Tunisia.

Biology
|November 27, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Inhaled toluene and noise exposure cause lung damage, oxidative stress, and inflammation. Olea europaea L. leaf extract (OLE) significantly protected against these harmful effects, showing potential for lung health.

Area of Science:

  • Environmental Toxicology
  • Pharmacology
  • Pulmonology

Background:

  • Occupational exposure to toluene and noise is common.
  • Toluene and noise can independently or synergistically impact respiratory health.
  • Olea europaea L. leaf extract (OLE) possesses antioxidant and anti-inflammatory properties.

Purpose of the Study:

  • To investigate pulmonary damage from toluene and noise exposure.
  • To evaluate the protective effects of Olea europaea L. leaf extract (OLE) against combined toluene and noise exposure.
  • To assess the impact of isolated toluene, isolated noise, and combined exposure on lung tissue.

Main Methods:

  • Forty-eight Wistar rats were divided into eight groups: control, OLE treatment, noise exposure, noise + OLE, toluene exposure, toluene + OLE, noise + toluene, and noise + toluene + OLE.
Keywords:
Olea europaea L. leaf extractantioxidant activitylung tissuenoise

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  • Animals received OLE (40 mg/kg/day) orally for six weeks.
  • Pulmonary damage was assessed via histological examination, oxidative stress markers (lipid peroxidation, catalase, superoxide dismutase), and pro-inflammatory cytokines (IL-6, IL-1β, TNF-α).

    • Main Results:

    • Toluene and combined toluene-noise exposure significantly disrupted pulmonary histology and induced oxidative stress.
    • Elevated lipid peroxidation, reduced antioxidant enzyme activity, and increased pro-inflammatory cytokines were observed in exposed groups.
    • Noise exposure alone had minimal effects but was associated with an inflammatory response.
    • OLE administration effectively mitigated oxidative stress, inflammation, and histological damage.

    Conclusions:

    • Combined exposure to toluene and noise exacerbates pulmonary damage, oxidative stress, and inflammation.
    • Olea europaea L. leaf extract (OLE) demonstrates significant protective effects against toluene and noise-induced lung injury.
    • OLE holds potential as a therapeutic agent for mitigating respiratory damage from environmental toxins.
    rat
    toluene