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Related Experiment Videos

[Cisplatin ototoxicity. A clinical study].

M Schröder, R Laskawi, E Stennert

    Laryngologie, Rhinologie, Otologie
    |February 1, 1986
    PubMed
    Summary
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    Cisplatin (cis-DDP) chemotherapy causes dose-dependent hearing loss in 48% of cancer patients, primarily affecting high frequencies. The severity of this ototoxicity depends on the platinum dose and administration method.

    Area of Science:

    • Ototoxicology
    • Clinical Oncology
    • Audiology

    Context:

    • Cisplatin (cis-DDP) is a widely used chemotherapy agent.
    • Ototoxicity, or hearing damage, is a known side effect of cisplatin.
    • Existing literature shows variability in reported hearing defect frequencies and extents.

    Purpose:

    • To analyze the ototoxic effects of cisplatin in cancer patients.
    • To investigate factors influencing cisplatin-induced ototoxicity, including patient age, platinum dose, administration method, and pre-existing audiometric anomalies.
    • To compare findings with existing clinical studies.

    Summary:

    • A study of 124 carcinoma patients revealed therapy-induced, dose-dependent hearing defects in 48% of cases.
    • Hearing impairment predominantly occurred in the high-frequency range (4-8 kHz).

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  • The degree of ototoxicity was influenced by cisplatin dosage and administration, with 100 mg/m² body surface area causing the most severe defects.

    • Impact:

    • Highlights the significant incidence of cisplatin-induced hearing loss in cancer patients.
    • Identifies key factors (dose, administration) that modulate ototoxicity risk.
    • Provides data for clinical management and patient counseling regarding hearing preservation during cisplatin therapy.