Related Experiment Video
Updated: Jun 6, 2025
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
9.5K
Differences in Gender and Overall Survival for Temperature-Sensitive TP53 Mutations in Gastroesophageal Cancer
Danial H Shaikh1, Margaret Park1,2, Jiandong Chen3
1Department of GI Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.
Medicina (Kaunas, Lithuania)
|November 27, 2024
Summary
Temperature-sensitive TP53 mutations in esophageal and gastric cancers did not significantly impact survival, despite a trend toward worse outcomes. Further research is needed to understand the unique prognostic value of these temperature-sensitive TP53 mutations.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- TP53 mutations are common in esophageal cancer (EC) and gastric cancer (GC).
- Temperature-sensitive (TS) TP53 mutants are inactive at body temperature but can be reactivated at lower temperatures.
- TS TP53 mutations may offer unique therapeutic or prognostic insights.
Purpose of the Study:
- To investigate the trends and outcomes of EC and GC with TS TP53 mutations.
- To determine if TS TP53 mutants have a distinct prognostic profile compared to non-TS TP53 mutants.
- To evaluate the association between TS TP53 status and overall survival in EC and GC patients.
Main Methods:
- Utilized cBioportal to identify 1924 patients with EC or GC and TP53 mutations.
- Stratified patients based on TP53 temperature sensitivity (TS vs. non-TS).
- Analyzed survival outcomes and compared populations based on mutation status, cancer stage, and other clinical factors.
Main Results:
- No association found between TS/non-TS TP53 status and Barrett's esophagus, cancer stage, or race.
- Females showed a significantly higher proportion of TS TP53 mutations (22.9%) compared to males (14.5%).
- No significant difference in overall survival was observed between TS and non-TS TP53 mutations in EC or GC.
Conclusions:
- While not statistically significant, a trend towards decreased overall survival was noted for patients with TS TP53 mutations.
- The findings suggest TS TP53 mutations may possess unique prognostic value.
- Further investigation is warranted to elucidate the role of TS TP53 mutations in cancer progression and outcomes.
Related Concept Videos
02:27Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K