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Related Concept Videos

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

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Substantive Dimethicone-Based Mucoadhesive Coatings.

Sophie Miller1, Nicole Omoto2, Ryan DeCamp1

  • 1Department of Chemistry, College of Arts and Sciences, Creighton University, Omaha, NE 68178, USA.

Materials (Basel, Switzerland)
|November 27, 2024
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Summary

This study developed a dimethicone-based oral carrier system for effective therapeutic delivery. The mucoadhesive material adheres to oral tissues, overcoming challenges like saliva washout for better treatment.

Keywords:
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Area of Science:

  • Biomaterials Science
  • Dental Therapeutics
  • Drug Delivery Systems

Background:

  • Oral drug delivery faces challenges due to wet surfaces, mucosal properties, and saliva washout.
  • Developing stable and adhesive oral carrier systems is crucial for effective therapeutic delivery.

Purpose of the Study:

  • To develop and evaluate a mucoadhesive dimethicone-based oral carrier system.
  • To assess the potential of this system for delivering therapeutics to oral hard tissues and mucosa.

Main Methods:

  • Investigated viscosity using a rheometer.
  • Measured mucoadhesion (work of adhesion, peak tack force) via tensile testing with a texture analyzer.
  • Examined mineral deposition using scanning electron microscopy after applying formulations with calcium/phosphate salts or sodium fluoride.

Main Results:

  • Characterized viscosity and mucoadhesion properties of dimethicone-based polymer blends.
  • Demonstrated mineral deposition on dental hard tissue surfaces following formulation application.
  • Confirmed the mucoadhesive potential of dimethicone-based materials in the oral environment.

Conclusions:

  • Dimethicone-based materials show promise as mucoadhesive carriers for oral therapeutic delivery.
  • These systems can potentially aid in remineralization and treating dentin hypersensitivity.
  • The developed carrier system effectively addresses challenges of the oral environment for drug delivery.