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Hemadsorption with CytoSorb in Infants with Sepsis: Non-Systematic Review of Cases

Aruzhan Borankulova1, Vitaliy Sazonov2,3

  • 1Department of Medicine, School of Medicine, Nazarbayev University, Astana Z05K4F4, Kazakhstan.

Journal of Clinical Medicine
|November 27, 2024
PubMed

Insights

CytoSorb hemadsorption effectively stabilizes hemodynamics in pediatric sepsis patients. This treatment reduces inflammatory markers and improves septic shock indicators, suggesting its value as a supplementary tool for young patients.

Area of Science:

  • Critical Care Medicine
  • Pediatric Infectious Diseases
  • Biomedical Engineering

Background:

  • Sepsis is a life-threatening condition where the body's response to infection damages organs.
  • Prompt treatment is crucial to prevent organ failure and death.
  • Pediatric sepsis presents unique challenges in management.

Purpose of the Study:

  • To review the use of CytoSorb hemadsorption in pediatric septic patients.
  • To evaluate the efficacy of CytoSorb in stabilizing hemodynamics and reducing inflammatory markers.
  • To assess CytoSorb as a supplementary treatment for sepsis in children.

Main Methods:

  • A nonsystematic review of case studies.
  • Literature search conducted on PubMed, Google Scholar, and Scopus.
  • Analysis of 11 pediatric cases from six journal articles.

Main Results:

  • Hemoperfusion with CytoSorb led to reductions in Interleukin (IL)-6 and IL-10 levels.
  • Significant decreases observed in C-reactive protein, lactate, procalcitonin, ALT, and AST in surviving patients.
  • CytoSorb demonstrated efficient hemodynamic stabilization and modulation of inflammatory response.

Conclusions:

  • CytoSorb appears effective in managing sepsis-related conditions in pediatric patients, including neonates and infants.
  • It serves as a valuable supplementary tool in pediatric sepsis management.
  • Development of age and weight-specific CytoSorb devices may be needed to overcome current limitations.

Keywords:
CytoSorbhemadsorptionneonate sepsispediatricssepsis

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