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Hyperbaric Oxygen Therapy Ameliorates Olanzapine-Induced Hypolocomotion in a Rat Model

  • 0Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
Life (basel, Switzerland) +

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November 27, 2024

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November 27, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Hyperbaric oxygen therapy (HBOT) may counteract olanzapine-induced (OLZ) locomotor impairment in rats. This non-pharmacological approach improved motor coordination without affecting antioxidant status, suggesting a potential therapeutic strategy.

Area Of Science

  • Neuroscience
  • Pharmacology
  • Biomedical Engineering

Background

  • Olanzapine (OLZ) is a widely used antipsychotic medication for schizophrenia.
  • OLZ treatment is associated with adverse effects, notably decreased locomotor activity and weight gain.
  • Research has primarily focused on metabolic side effects, with less attention on motor impairments.

Purpose Of The Study

  • To investigate the efficacy of hyperbaric oxygen therapy (HBOT) in mitigating OLZ-induced locomotor deficits.
  • To assess HBOT's impact on motor coordination and brain tissue antioxidant capacity in rats treated with OLZ.

Main Methods

  • Female Sprague Dawley rats were divided into four groups: control, HBOT, OLZ, and HBOT + OLZ.
  • Locomotor activity and coordination were evaluated using a rotarod test.
  • Total antioxidant capacity (TAC) in brain tissue was measured to assess biochemical changes.

Main Results

  • HBOT significantly counteracted the hypolocomotion induced by OLZ administration.
  • HBOT did not negatively impact the total antioxidant capacity (TAC) in brain tissue.
  • The findings suggest HBOT preserves OLZ's effectiveness in improving antioxidant status.

Conclusions

  • HBOT shows promise as a non-pharmacological intervention for OLZ-associated locomotor impairments.
  • This approach may help manage motor coordination deficits in patients undergoing OLZ treatment.
  • Further research is warranted to explore HBOT's therapeutic potential in psychiatric pharmacotherapy.

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