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Customizable Self-Microemulsifying Rectal Suppositories by Semisolid Extrusion 3D Printing.
1BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE, MRC), Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea.
Pharmaceutics
|November 27, 2024
Summary
This study developed a novel 3D-printed suppository using self-microemulsifying drug delivery systems for ibuprofen. The innovative formulation enhances ibuprofen rectal absorption and bioavailability.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Biomedical Engineering
Background:
- Traditional ibuprofen suppositories have limitations in rectal absorption.
- Developing advanced drug delivery systems is crucial for enhancing therapeutic efficacy.
Purpose of the Study:
- To create a novel self-microemulsifying drug delivery system (SMEDDS) suppository for ibuprofen (IBU) utilizing semisolid extrusion (SSE) three-dimensional (3D) printing.
- To evaluate the physicochemical properties, content uniformity, and dissolution profiles of the 3D-printed suppositories.
Main Methods:
- Formulation of SMEDDS using selected oil, surfactant, and co-surfactant based on solubility and microemulsion formation.
- Fabrication of IBU-loaded SMEDDS suppositories using SSE 3D printing technology in various sizes and drug contents.
- Comprehensive characterization including differential scanning calorimetry, X-ray diffraction, FTIR, and in vitro dissolution testing.
Main Results:
- The SMEDDS formulation exhibited suitable properties for 3D printing, yielding nano-sized emulsion droplets.
- IBU was found to be in an amorphous state within the formulation.
- The 3D-printed SMEDDS suppositories demonstrated a significantly higher initial dissolution rate compared to IBU powder.
Conclusions:
- The developed SMEDDS-3DPS suppository enhances the rectal bioavailability of ibuprofen.
- SSE 3D printing offers a versatile, adaptable, and simple manufacturing method for customized lipid-based suppositories.
- This technology presents a novel approach to suppository production, potentially surpassing traditional methods.
Keywords:
SMEDDS suppositorycustomized suppositoriesdissolution profilesibuprofensemisolid extrusion 3D printing
