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Updated: Jun 6, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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Advancements in p53-Based Anti-Tumor Gene Therapy Research

Yuanwan Peng1, Jinping Bai1, Wang Li1

  • 1Institute of Modern Fermentation Engineering and Future Foods, School of Light Industry and Food Engineering, Guangxi University, No. 100, Daxuedong Road, Nanning 530004, China.

Molecules (Basel, Switzerland)
|November 27, 2024
PubMed

Insights

p53 gene therapy shows promise for cancer treatment but faces challenges. This review explores advances in p53 gene therapy and nucleic acid delivery to overcome these hurdles and support future development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Therapy

Background:

  • The p53 gene is a critical tumor suppressor frequently altered in human cancers.
  • p53-based gene therapy is a promising strategy for cancer treatment.
  • Current p53 gene therapies face significant challenges including immaturity, safety concerns, limited efficacy, and patient acceptance.

Purpose of the Study:

  • To review recent advances in p53-based gene therapy.
  • To examine progress in nucleic acid delivery technologies for p53 gene therapy.
  • To provide insights and prospects for future development in this field.

Main Methods:

  • Literature review of p53 gene therapy.
  • Analysis of nucleic acid delivery systems.
  • Discussion of challenges and future directions.

Main Results:

  • Significant progress has been made in p53 gene therapy development.
  • Novel nucleic acid delivery technologies are emerging to improve therapeutic outcomes.
  • Despite challenges, the theoretical potential of p53 gene therapy remains high.

Conclusions:

  • Further research and technological advancements are crucial for overcoming current limitations.
  • Improved nucleic acid delivery systems are key to enhancing p53 gene therapy efficacy and safety.
  • p53 gene therapy holds considerable potential for future cancer treatment strategies.
Keywords:
delivery vectorgene therapyp53tumor

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