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Plasma triglycerides related decrease in high-density lipoprotein cholesterol and its association with myocardial
Metabolism: Clinical and Experimental
|April 1, 1986
Summary
Familial hypercholesterolemia (FH) patients show significantly lower high-density lipoprotein (HDL) cholesterol levels, strongly linked to elevated triglycerides and body weight, increasing ischemic heart disease risk.
Area of Science:
- Cardiovascular Medicine
- Lipid Metabolism
- Genetics
Background:
- Familial hypercholesterolemia (FH) is linked to premature atherosclerosis.
- Decreased high-density lipoprotein (HDL) cholesterol may be a risk factor in FH.
Purpose of the Study:
- To analyze HDL cholesterol concentration and distribution in FH subjects.
- To investigate the relationship between HDL, triglycerides, and ischemic heart disease in FH.
Main Methods:
- Study included 71 men with heterozygous FH and 46 controls.
- Measured HDL cholesterol, plasma triglycerides, VLDL, LDL, and total cholesterol.
- Assessed prevalence of tendon xanthomas and ischemic heart disease.
Main Results:
- FH heterozygotes had 21% lower HDL cholesterol than controls (33 vs 42 mg/dL).
- Reduced HDL cholesterol strongly correlated with higher plasma triglycerides and VLDL cholesterol.
- HDL decrease was not associated with LDL cholesterol but weakly with total cholesterol and body weight.
Conclusions:
- Decreased HDL cholesterol is a significant finding in FH heterozygotes.
- Elevated triglycerides and body weight contribute to reduced HDL levels in FH.
- Further research is needed to understand the atherogenic role of HDL in FH.