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Chokeberry Products and By-Products as the Potential Pharmaceuticals for Kidney Protection-An Experimental Study in

Milica Milutinović1, Nada Ćujić Nikolić2, Tatjana Cvetković3,4

  • 1Department of Pharmacy, Faculty of Medicine, University of Niš, Bul. Dr Zorana Đinđića 81, 18000 Niš, Serbia.

Plants (Basel, Switzerland)
|November 27, 2024
PubMed

Insights

Chokeberry products, including waste, protect against cisplatin-induced kidney damage by reducing oxidative stress and inflammation. Waste extract showed superior protective effects due to higher polyphenol content.

Area of Science:

  • Pharmacology
  • Toxicology
  • Natural Products Chemistry

Background:

  • Cisplatin chemotherapy can cause acute kidney injury (AKI).
  • Oxidative stress and inflammation are key mechanisms in cisplatin nephrotoxicity.
  • Chokeberry (Aronia) is rich in bioactive compounds with potential antioxidant and anti-inflammatory properties.

Purpose of the Study:

  • To evaluate the protective effects of chokeberry fruit products and by-products against cisplatin-induced nephrotoxicity in rats.
  • To investigate the underlying mechanisms, focusing on oxidative stress and inflammation.
  • To assess the pharmaceutical potential of chokeberry waste.

Main Methods:

  • Rats were treated with chokeberry juice, whole fruit extract, or waste extract before cisplatin administration.
  • Biochemical markers of kidney function (creatinine, BUN), oxidative stress (lipid peroxidation, glutathione, catalase), and inflammation (IL-1β, TNF-α, IL-6) were measured.
  • Kidney tissues were analyzed histopathologically.

Main Results:

  • Cisplatin induced significant nephrotoxicity, evidenced by elevated creatinine and BUN, increased lipid peroxidation, and reduced antioxidant enzyme activity.
  • Pro-inflammatory cytokine levels (IL-1β, TNF-α, IL-6) were significantly increased post-cisplatin treatment.
  • Chokeberry preparations significantly ameliorated cisplatin-induced kidney damage and biochemical alterations.
  • The chokeberry waste extract exhibited the most potent protective effects.

Conclusions:

  • Chokeberry, particularly its waste by-products, demonstrates significant nephroprotective potential against cisplatin-induced toxicity.
  • The protective mechanisms involve the mitigation of oxidative stress and inflammatory responses.
  • Chokeberry by-products represent a valuable source of bioactive compounds for pharmaceutical applications in kidney protection.
Keywords:
chokeberry fruitcisplatin-induced nephrotoxicityextracthistopathological examinationinflammatory markersjuiceoxidative stress markersratswaste by-products

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