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Related Concept Videos

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Factors Affecting Illness01:18

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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Updated: Jun 6, 2025

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
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Infectious Disease as a Modifiable Risk Factor for Dementia: A Narrative Review.

Thomas J Farrer1, Jonathan D Moore1, Morgan Chase2

  • 1Idaho WWAMI Medical Education Program, University of Idaho, Moscow, ID 83844, USA.

Pathogens (Basel, Switzerland)
|November 27, 2024
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Summary
This summary is machine-generated.

Preventing infectious diseases, through vaccinations and antivirals, may reduce dementia risk. Public health strategies should incorporate infection control to combat the growing dementia burden.

Keywords:
antiviral treatmentdementia preventioninfectious diseaseneuroinflammationvaccinations

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • The global aging population is experiencing a rise in Alzheimer's disease and related dementias.
  • Limited efficacy of current dementia treatments necessitates a focus on prevention.
  • Emerging evidence suggests infectious diseases are modifiable risk factors for dementia.

Purpose of the Study:

  • To review the link between infectious diseases and dementia risk.
  • To explore preventive measures against dementia through infection control.
  • To examine potential mechanisms, such as neuroinflammation, linking infections and dementia.

Main Methods:

  • Narrative review of existing scientific literature.
  • Analysis of studies on viral and bacterial infections and dementia.
  • Evaluation of preventive strategies including vaccinations and antiviral therapies.

Main Results:

  • Vaccinations (influenza, herpes zoster, hepatitis) and antiviral treatments (human herpesvirus) may reduce dementia incidence.
  • Non-pharmaceutical interventions are effective in reducing infectious disease spread, potentially lowering dementia risk.
  • Reduced systemic inflammation is a proposed mechanism for the protective effects of these interventions.

Conclusions:

  • Infectious disease prevention should be integrated into public health strategies to mitigate dementia burden.
  • While associations exist, further research is needed to confirm causality and biological mechanisms.
  • Exploring preventive measures across diverse populations is crucial for understanding their impact on dementia risk.