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Host-Driven Ubiquitination Events in Vector-Transmitted RNA Virus Infections as Options for Broad-Spectrum

Sanskruthi Sreepangi1, Haseebullah Baha1, Lorreta Aboagyewa Opoku1

  • 1School of Systems Biology, College of Science, George Mason University, Fairfax, VA 22030, USA.

Viruses
|November 27, 2024
PubMed

Insights

Ubiquitination, a key protein modification, is crucial for vector-borne virus replication and pathogenesis. Targeting ubiquitination pathways offers potential for developing new antiviral countermeasures.

Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Background:

  • Vector-borne viruses pose significant public health challenges, with limited understanding of virus-host interactions.
  • Protein ubiquitination is a critical post-translational modification regulating protein function, signaling, and degradation.
  • Viruses exploit host ubiquitination machinery for replication and to evade antiviral defenses.

Purpose of the Study:

  • To review the role of E3 ligase-mediated ubiquitination in the life cycle of vector-transmitted viruses.
  • To explore how ubiquitination impacts viral pathogenesis and host antiviral responses.
  • To identify therapeutic targets within ubiquitination pathways for developing novel countermeasures.

Main Methods:

  • Literature review focusing on E3 ligase-regulated ubiquitination pathways.
  • Analysis of proviral and antiviral roles of ubiquitination in vector-borne viral infections.
  • Examination of therapeutic strategies targeting ubiquitination.

Main Results:

  • Viral proteins hijack host ubiquitination machinery to modulate host processes, including antiviral defenses.
  • Host ubiquitination machinery modifies viral proteins, aiding viral assembly and egress.
  • E3 ligases act as both proviral factors and viral restriction factors.

Conclusions:

  • Understanding ubiquitination's role in vector-borne viral infections is crucial for advancing knowledge of viral pathogenesis.
  • Targeting E3 ligase-regulated ubiquitination pathways presents a promising avenue for developing effective antiviral countermeasures.
Keywords:
alphavirusesbunyavirusesflaviviruseshost–virus interactionsubiquitin E3 ligasesubiquitinationvector-transmitted viruses

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