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Updated: Jun 6, 2025

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
Published on: August 8, 2020
How Did This Happen? Xenograft Conversion to Dermal Scaffolding after Scalding Grease Burn
Aurelie Tran1, Elizabeth Windell2, Luke Pumiglia3
1Division of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
Xenograft and other biologic dressings have been an integral part of burn care for many years. Porcine graft is both inexpensive and, for partial thickness burns, provides the additional benefit of avoiding painful dressing changes when compared with topical agents. In this case, we discuss a patient suffering from deep partial thickness burns for whom xenograft was used for initial wound coverage. This porcine graft became unexpectedly incorporated, and the patient ultimately underwent operative debridement and autologous re-grafting. The case demonstrates a gap in the understanding of wound-healing mechanisms around porcine xenografts and raises the potential for future innovation in expedited wound healing using xenografting.
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