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Updated: Jun 6, 2025

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Homochiral Self-Sorting During Macrocycle Formation and their Chiroptical Properties
1School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram (IISER-TVM), 695551, Thiruvananthapuram, India.
Abstract:
Several BINOL-derived C2-symmetric aldehydes were synthesized to investigate chiral self-sorting phenomena during macrocycle formation in the presence of aliphatic and aromatic bisamines. While self-sorting was unsuccessful with aliphatic amines, aromatic amine dictated complete homochiral self-sorting, confirmed by 1H NMR analysis and molecular modelling. Additionally, the impact of macrocyclization on the chiroptical properties of these macrocycles was examined. The Cotton effects band red-shifted for aromatic amines owing to extended conjugation. Notably, a substantial increase in specific rotation was observed upon macrocycle formation.
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