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Infection with Listeria monocytogenes meningoencephalitis: A case report

Da-Zhen Xu1, Quan-Hui Tan2

  • 1Department of Nursing, Shanghai Sixth People's Hospital, Shanghai 200233, China.

World Journal of Clinical Cases
|November 27, 2024
PubMed
Abstract

Insights

Metagenomic sequencing (mNGS) aids rapid Listeria meningitis diagnosis. This approach supports timely treatment for patients, especially those unresponsive to initial therapies.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Microbiology

Background:

  • Listeria meningitis is a severe CNS infection caused by *Listeria monocytogenes*, a ubiquitous bacterium.
  • Traditional diagnostics like CSF culture and serology have limitations including time, low positivity rates, and potential inaccuracies.
  • Metagenomic sequencing (mNGS) offers a significant advancement for rapid and accurate pathogen detection in infectious meningitis.

Observation:

  • A case study involving a previously healthy 64-year-old woman diagnosed with Listeria meningitis.
  • The diagnosis was achieved using metagenomic sequencing (mNGS).

Findings:

  • Metagenomic sequencing enabled a quick and accurate diagnosis of Listeria meningitis.
  • The patient received successful treatment with intravenous ampicillin and meropenem.

Implications:

  • Listeria meningitis should be suspected in patients with refractory symptoms to first-line antibiotics.
  • mNGS technology accelerates diagnosis, facilitating prompt and effective patient treatment.
Keywords:
Case reportDiagnosisImmune functionListeria monocytogenesMeningitisTreatment

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