Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vitamins01:30

Vitamins

563
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
563
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
Development of Immunocompetence01:22

Development of Immunocompetence

288
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
288
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

909
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
909
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

11.4K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating emergency rescue readiness on Indian national highways: A case study of Jaipur-Jodhpur Highways (India) using a geospatial approach.

Journal of family medicine and primary care·2024
Same author

Analysis of the Thickness of Ligamentum Flavum and Its Relationship With Degenerative Disc Changes at L3-4, L4-5, and L5-S1 Levels in Patients Undergoing Magnetic Resonance Imaging (MRI) of the Lumbosacral Spine.

Cureus·2024
Same author

Constrictive pericarditis following epicardial pacemaker implant: a diagnostic dilemma.

Cardiology in the young·2024
Same author

Collaboration Across Disciplines to Integrate Clinical Expertise into Medical Software Development: The Approach of the Dedalus Medical Office.

Studies in health technology and informatics·2024
Same author

Nanoparticle Carriers: A New Era of Precise CRISPR/Cas9 Gene Editing.

MicroRNA (Shariqah, United Arab Emirates)·2024
Same author

Dynamic Dance of Chirality and Morphology: Interplay of Solvent-Sensitive Self-Assembly in Topological Evolution and Chirality Amplification.

ACS applied materials & interfaces·2024
Same journal

Retraction: The Association Between Janus Kinase 2 and Factor V Leiden Mutations and Thrombotic Complications in Patients With Myeloproliferative Disorders: A Study From Saudi Arabia.

Cureus·2026
Same journal

Patient-Reported Understanding of Emergency Department Discharge Instructions, Satisfaction, and Acceptability of a Future Telemedicine-Based Call-Back Program: Phase 1 Observational Pilot Study at a Tertiary Hospital in Dubai, United Arab Emirates.

Cureus·2026
Same journal

Correction: Methylprednisolone-Induced Delayed and Sustained Bradycardia in Multisystem Inflammatory Syndrome in Children.

Cureus·2026
Same journal

Rapid Interval Development of a Left Hepatic Artery Pseudoaneurysm During Acute Interstitial Edematous Pancreatitis.

Cureus·2026
Same journal

Recurrent Acute Pancreatitis Secondary to Untreated Hyperparathyroidism: A Case Report and Literature Review.

Cureus·2026
Same journal

A Prospective Case-Control Study of Helicobacter pylori and Systemic Inflammation in Colorectal Cancer Pathogenesis.

Cureus·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.3K

Association Between Vitamin D Deficiency and Sepsis in Term Neonates: A Case-Control Study.

Jasleen Dua1, Renuka S Jadhav1, Mridu Bahal1

  • 1Pediatrics, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.

Cureus
|November 27, 2024
PubMed
Summary
This summary is machine-generated.

Neonatal sepsis is linked to lower vitamin D levels. Vitamin D deficiency in newborns is associated with increased risk and severity of early-onset sepsis, highlighting its role in immune defense.

Keywords:
immunomodulatory propertiesneonatal sepsisserum levelsterm neonatesvitamin d

More Related Videos

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

10.9K
A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

147

Related Experiment Videos

Last Updated: Jun 6, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.3K
A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

10.9K
A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

147

Area of Science:

  • Neonatology
  • Immunology
  • Nutritional Science

Background:

  • Neonatal sepsis is a significant cause of infant mortality globally.
  • Early identification and prevention of neonatal sepsis remain challenging.
  • Vitamin D is increasingly recognized for its immunomodulatory functions beyond bone health.

Purpose of the Study:

  • To compare serum vitamin D levels in term neonates with and without sepsis.
  • To investigate the association between vitamin D status and neonatal sepsis.

Main Methods:

  • A case-control study involving 60 term neonates (30 sepsis cases, 30 controls).
  • Serum vitamin D levels were measured using chemiluminescent microparticle immunoassay (CMIA).
  • Clinical data including mode of delivery, meconium staining, and Apgar scores were collected.

Main Results:

  • Term neonates with sepsis had significantly lower mean serum vitamin D levels (16.0 ng/mL) compared to controls (29.07 ng/mL) (p<0.01).
  • Sepsis cases showed lower Apgar scores and higher rates of meconium-stained liquor and intrapartum antibiotic use.
  • Vitamin D deficiency was strongly associated with severe, early-onset neonatal sepsis.

Conclusions:

  • Lower serum vitamin D levels are significantly associated with neonatal sepsis.
  • Vitamin D deficiency may play a role in the susceptibility and severity of early-onset sepsis in term neonates.
  • Further research into vitamin D supplementation for sepsis prevention/treatment is warranted.