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Updated: May 2, 2026
Optimization of Renal Organoid and Organotypic Culture for Vascularization, Extended Development, and Improved Microscopy Imaging
Published on: March 28, 2020
Construction methods and latest applications of kidney cancer organoids
Zhiqiang Li1, Yanqiu You2, Bingzheng Feng2
1Medical College of Guangxi University, Nan Ning, Guang Xi, China.
Abstract:
Renal cell carcinoma (RCC) is one of the deadliest malignant tumors. Despite significant advances in RCC treatment over the past decade, complete remission is rarely achieved. Consequently, there is an urgent need to explore and develop new therapies to improve the survival rates and quality of life for patients. In recent years, the development of tumor organoid technology has attracted widespread attention as it can more accurately simulate the spatial structure and physiological characteristics of tumors within the human body. In this review, we summarize the main methods currently used to construct kidney cancer organoids, as well as their various biological and clinical applications. Furthermore, combining organoids with other technologies, such as co-culture techniques and microfluidic technologies, can further develop organoids and address their limitations, creating more practical models. This approach summarizes the interactions between different tissues or organs during tumor progression. Finally, we also provide an outlook on the construction and application of kidney cancer organoids. These rapidly evolving kidney cancer organoids may soon become a focal point in the development of in vitro clinical models and therapeutic research for kidney cancer.
Insights
Kidney cancer organoids offer a realistic 3D model for studying renal cell carcinoma (RCC). This review details their construction, applications, and potential to advance new cancer therapies.
Area of Science:
- Oncology
- Biotechnology
- Regenerative Medicine
Background:
- Renal cell carcinoma (RCC) remains a deadly cancer with limited treatment success.
- Advanced therapies are crucial for improving patient survival and quality of life.
- Tumor organoid technology provides a promising in vitro model for cancer research.
Purpose of the Study:
- To review methods for constructing kidney cancer organoids.
- To explore the biological and clinical applications of these organoids.
- To discuss advancements and future directions in kidney cancer organoid development.
Main Methods:
- Summarizing current techniques for building kidney cancer organoids.
- Highlighting the integration of organoids with co-culture and microfluidic technologies.
- Analyzing the simulation of tumor spatial structure and physiological characteristics.
Main Results:
- Organoids accurately mimic in vivo tumor environments.
- Combined technologies enhance organoid models for studying tissue interactions.
- Kidney cancer organoids show significant potential in preclinical research.
Conclusions:
- Kidney cancer organoids are rapidly evolving tools for in vitro research.
- These models can accelerate the development of novel therapeutic strategies for RCC.
- Organoid technology is poised to become central to kidney cancer clinical models and drug discovery.
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