Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

VRK1-Related Motor Neuropathy With Upper Motor Neuron Signs and Selective Muscle Involvement.

Journal of the peripheral nervous system : JPNS·2026
Same author

Muscle Regeneration Failure May Lead to Clinical Features of Myopathy in Anti-IgLON5 Disease.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

Exploring Dystrophin Expression and Mutations in the <i>DMD</i> and Dystrophin-Glycoprotein Complex Genes as Prognostic Factors in Leiomyosarcomas.

International journal of molecular sciences·2026
Same author

Specific HLA-DRB1 Alleles Associate With Anti-Caspr1 and Anti-CNTN1 Autoantibodies in Autoimmune Nodopathies.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

Prognostic Determinants of Presentation and Outcome in Anti-IgLON5 Disease.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

Comprehensive neuropsychological assessment and FDG-PET imaging in patients with RFC1-related disorder.

Parkinsonism & related disorders·2026

Related Experiment Video

Updated: May 23, 2026

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
11:29

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

Published on: January 3, 2011

26.5K

Long-Term Follow Up in Anti-Contactin-1 Autoimmune Nodopathy.

Marta Caballero-Ávila1, Lorena Martín-Aguilar1, Elba Pascual-Goñi1

  • 1Neuromuscular Diseases Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Sant Pau Biomedical Research Institute (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.

Annals of Neurology
|November 27, 2024
PubMed
Summary

Autoimmune nodopathy linked to anti-contactin-1 (CNTN1) antibodies presents a distinct clinical picture. Effective treatment with rituximab leads to infrequent relapses, and biomarkers like anti-CNTN1, sNfL, and sCNTN1 can monitor disease status.

More Related Videos

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

14.1K
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
07:30

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Published on: November 9, 2017

9.3K

Related Experiment Videos

Last Updated: May 23, 2026

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
11:29

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

Published on: January 3, 2011

26.5K
Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

14.1K
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
07:30

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Published on: November 9, 2017

9.3K

Area of Science:

  • Neurology
  • Immunology
  • Autoimmune Diseases

Background:

  • Anti-contactin-1 (CNTN1) autoimmune nodopathy (AN) is a rare neurological disorder.
  • Understanding its long-term clinical course and biomarker behavior is crucial for patient management.

Purpose of the Study:

  • To analyze the long-term clinical and biomarker features of anti-CNTN1 autoimmune nodopathy.
  • To evaluate treatment responses and disease monitoring strategies in affected patients.

Main Methods:

  • Retrospective analysis of clinical data and autoantibody levels from 31 patients with anti-CNTN1 AN.
  • Assessment of serum neurofilament light chain (sNfL) and serum CNTN1 (sCNTN1) levels at baseline and follow-up.
  • Evaluation of treatment responses, particularly to rituximab, and monitoring for relapses.

Main Results:

  • Patients typically presented with progressive sensory motor neuropathy, ataxia, and severe disability, with some experiencing kidney involvement.
  • Rituximab demonstrated high efficacy (95.5%) with a single course in most patients, leading to normalization of anti-CNTN1 titers, sNfL, and sCNTN1 levels.
  • Clinical and immunological relapses were infrequent after successful treatment, with anti-CNTN1 titers correlating with disease activity.

Conclusions:

  • Anti-CNTN1 autoimmune nodopathy has a characteristic clinical profile and generally infrequent relapses post-treatment.
  • Continuous treatment may not be necessary, and anti-CNTN1 antibodies, sNfL, and sCNTN1 are valuable biomarkers for disease monitoring.
  • This study highlights the effectiveness of rituximab and the utility of biomarkers in managing anti-CNTN1 AN.