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The Association between Serum Lipid Profile Levels and Hypertension Grades: A Cross-Sectional Study at a Health
Ling Huang1, Zhangyi Liu1, Huayang Zhang1
1Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, School of Nursing, Southwest Medical University, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China.
Insights
Elevated triglycerides and LDL cholesterol correlate with all hypertension grades. Very high HDL cholesterol is linked to severe hypertension, highlighting lipid profiles
Area of Science:
- Cardiovascular Medicine
- Clinical Biochemistry
- Epidemiology
Background:
- Hypertension and dyslipidemia are significant cardiovascular risk factors frequently occurring together.
- Hyperlipidemia is a critical, modifiable factor in preventing cardiovascular disease.
Purpose of the Study:
- To investigate the association between lipid levels and hypertension grading in a community-based adult population.
- To identify influencing factors on the relationship between hypertension and lipid profiles.
Main Methods:
- A cross-sectional study of 63,091 adults, measuring blood pressure, BMI, glucose, liver enzymes, renal function, and lipid profiles (TC, TG, LDL-c, HDL-c).
- Multivariate logistic regression and statistical charts were employed to analyze hypertension prevalence and lipid parameters.
- P-value < 0.05 was considered statistically significant.
Main Results:
- Increased triglycerides (TG) and low-density lipoprotein cholesterol (LDL-c) correlated with higher hypertension prevalence.
- Higher high-density lipoprotein cholesterol (HDL-c) was associated with a decreased prevalence of hypertension.
- Elevated TG and LDL-c were seen across all hypertension grades; very high HDL-c was linked to grade III hypertension.
Conclusions:
- Hyperlipidemia and hypertension frequently coexist in health examination populations.
- Elevated TG and LDL-c are associated with all hypertension grades.
- Extremely high HDL-c levels are linked to more severe hypertension.
Introduction:
Hypertension and dyslipidemia are major cardiovascular risk factors that often coexist. Hyperlipidemia is a crucial modifiable risk factor in preventing cardiovascular disease.
Aim:
We aimed to explore the relationship between lipid levels and the grading of hypertension in a community-based adult population.
Methods:
A total of 63,091 non-employed individuals were included in this study. Measurements included systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), fasting plasma glucose (FPG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (STB), serum creatinine (SCr), blood urea nitrogen (BUN), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c). Chi-square and t-tests were used to obtain basic population characteristics. Multivariate logistic regression was used to evaluate the association between the prevalence of hypertension and lipid profiles, as well as to identify influencing factors. A P-value < 0.05 was considered statistically significant. Statistical charts were utilized to analyze the relationship between lipid parameters and hypertension grades.
Results:
A total of 30,588 men and 32,503 women with an average age of 64.57 ± 12.5 years participated in this study. After adjusting STB and TC, every 1 mmol/L increase in TG and LDL-c was associated with a 6.0% and 6.5% increase in the prevalence of hypertension, respectively. Conversely, for every 1 mmol/L increase in HDL-c, the prevalence of hypertension decreased by 4.1%. Increases in TG and LDL-c levels were observed across all grades of hypertension, while very high HDL-c was significantly associated in grade III hypertension (1.54→1.66 mmol/L). Additionally, age, BMI, FPG, ALT, AST, SCr, and BUN significantly influenced the association between hypertension and lipid levels.
Conclusion:
Hyperlipidemia and hypertension often coexist in health examination populations. Elevated levels of TG and LDL-C are associated with all grades of hypertension, while extremely high HDL-C level is linked to more severe hypertension.
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